Variant Detail Page¶
The variant detail page provides comprehensive information about a single variant, with content visibility based on the variant's AMP/ASCO/CAP tier classification.
Overview¶
When viewing a variant, the page displays different sections depending on the clinical significance tier. This ensures that clinically relevant information is prominently displayed for actionable variants, while less relevant details are hidden for benign or unknown significance variants.
Tier-Based Widget Visibility¶
Different sections of the variant detail page are shown or hidden based on the variant's clinical significance tier:
| Section | Tier I-A | Tier I-B | Tier II | Tier III | Tier IV |
|---|---|---|---|---|---|
| Variant Info + Descriptions | Full | Full | Full | Full | Full |
| AMP Tier + Classifications | Full | Full | Full | Minimal | Minimal |
| FDA Therapies (Patient's Tumor) | Show | - | - | - | - |
| FDA Therapies (Other Tumors) | - | Show | Show | - | - |
| NCCN Guidelines (Patient's Tumor) | Show | Show | - | - | - |
| NCCN Guidelines (Other Tumors) | - | Show | Show | - | - |
| CKB Therapeutic Evidence | Show | Show | Show | - | - |
| CIViC Evidence | Show | Show | Show | - | - |
| Clinical Trials | Show | Show | Show | - | - |
| Manual Classification | Show | Show | Show | Show | Show |
| Comments | Show | Show | Show | Show | Show |
Tier Definitions¶
Tier I - Actionable¶
Tier I-A: Biomarkers that predict response or resistance to FDA-approved therapies for a specific type of tumor, or biomarkers included in professional guidelines.
Tier I-B: Biomarkers with strong clinical significance based on well-powered studies with consensus from experts in the field.
For Tier I variants, the page displays:
- Full clinical evidence including FDA-approved therapies
- NCCN practice guidelines
- CKB Genomenon therapeutic evidence
- CIViC evidence
- Relevant clinical trials
Tier II - Potential Significance¶
Biomarkers with potential clinical significance based on emerging evidence, CKB Level 5 evidence, or guidelines applicable to other tumor types.
For Tier II variants, the page displays:
- FDA-approved therapies for other tumor types
- NCCN guidelines for other tumor types
- CKB therapeutic evidence
- CIViC evidence
- Relevant clinical trials
Tier III - Unknown Significance¶
Variants of unknown clinical significance with insufficient evidence for therapeutic actionability.
For Tier III variants, the page displays:
- Basic variant information
- Minimal AMP tier display
- Manual classification section for expert review
- Comments for discussion
Tier IV - Benign¶
Variants classified as benign or likely benign with no clinical action recommended.
For Tier IV variants, the page displays:
- Basic variant information
- Minimal AMP tier display
- Manual classification section
- Comments
View Name Display¶
The page header displays the somatic view name corresponding to the detected tier:
- Tier I - Actionable: For Tier I-A and I-B variants
- Tier II - Potential Significance: For Tier II variants
- Tier III - Unknown Significance: For Tier III variants
- Tier IV - Benign: For Tier IV variants
This badge helps users quickly identify the clinical significance category of the variant they are reviewing.
Manual Classification¶
All tiers allow manual AMP/ASCO/CAP classification. This enables clinical experts to:
- Override or confirm automated tier assignments
- Add classification rationale
- Track classification history
Comments¶
All tiers support the comments section, enabling collaboration and discussion about variant interpretation regardless of the automated classification.