Phenotype panel builder¶
The builder turns a patient's observed phenotype into a ranked list of candidate genes, which you can save as a gene panel. It uses the Human Phenotype Ontology (HPO): you pick the phenotype terms that describe the patient, and iFlow ranks genes by how strongly the diseases matching those phenotypes implicate them.
Open it from Panels → Build from phenotype.
Build a panel¶
- Search phenotypes. Start typing in the search box (e.g. seizure, microcephaly) and pick matching HPO terms. Each one you add becomes a chip under Selected phenotypes; remove a chip with the ✕.
- Rank genes. Click Rank genes. iFlow scores the diseases that match your terms and aggregates those scores per gene, returning a ranked table (gene, score, number of contributing diseases).
- Save as panel. Enter a name and click Save as panel — the ranked genes are saved as a normal gene panel you can use anywhere a panel is accepted. You're taken to the new panel's page.
You can also export the ranked genes as TSV or JSON without saving.
Reproducibility
Rankings come from a pinned HPO data release, so the same phenotypes give the same genes until the release is deliberately updated.
Tips¶
- Add several specific phenotypes rather than one broad term — specificity sharpens the ranking.
- The saved panel is a plain gene list; review and trim it on the panel detail page or by editing before clinical use.